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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZALEPLON
| ZALEPLON | NERVOUS SYSTEM | ORAL | Cmax 980 NANOMOLAR (PMID18621671) Tmax 1 HOUR F 30 PERCENT VD 91 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 195 LITER / HOUR (65 KILOGRAM) HT 1 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA) BRAIN OMEGA-1 RECEPTOR | GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
