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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RISEDRONATE
| RISEDRONATE |
MUSCULO-SKELETAL | ORAL | Tmax 1 HOUR F 0.63 PERCENT VD 897 LITER (65 KILOGRAM) PPB 24 PERCENT Cl 7.3 LITER / HOUR HT 561 HOUR SOLUBILITY SOLUBLE IN WATER | FARNESYL PYROPHOSPHATE SYNTHASE PDB 4KPD (CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (Y204F) MUTANT COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE) LIGAND CODE = RIS (link to the list of PDB complexes) Download experimental 3D coordinates of RIS with added hydrogens | Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS more at DrugCentral | EMA | |||
