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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SULFASALAZINE (has an active metabolite)
| SULFASALAZINE | METABOLISM | ORAL | Cmax 15 MICROMOLAR Tmax 6 HOUR F 15 PERCENT VD 7.5 LITER PPB 99.3 PERCENT Cl 1 LITER / HOUR HT 7.6 HOUR | Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 -- Cyclooxygenase UNIPROT P23219 PTGS1 more at DrugCentral | EMA | ||||
