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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BRINZOLAMIDE
| BRINZOLAMIDE | SENSORY | OPHTHALMIC | Tmax 1 HOUR PPB 60 PERCENT HT 2664 HOUR SOLUBILITY INSOLUBLE IN WATER | CARBONIC ANHYDRASE II PDB 4M2V (GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX IN COMPLEX WITH BRINZOLAMIDE) LIGAND CODE = BZ1 (link to the list of PDB complexes) Download experimental 3D coordinates of BZ1 with added hydrogens | Carbonic anhydrase 2 UNIPROT P00918 CA2 more at DrugCentral | EMA | |||
