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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RALOXIFENE
| RALOXIFENE | GENITO | ORAL | Cmax 1.05 NANOMOLAR F 2 PERCENT VD 152620 LITER (65 KILOGRAM) PPB 95 PERCENT Cl 2866 LITER / HOUR (65 KILOGRAM) HT 27.7 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | ESTROGEN RECEPTOR BETA PDB 1ERR (HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE) LIGAND CODE = RAL (link to the list of PDB complexes) Download experimental 3D coordinates of RAL with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 more at DrugCentral | EMA | |||
