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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ENTACAPONE
| ENTACAPONE | NERVOUS SYSTEM | ORAL | Cmax 3.93 MICROMOLAR Tmax 1 HOUR F 35 PERCENT VD 20 LITER PPB 98 PERCENT Cl 51 LITER / HOUR HT 0.9 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | CATECHOL O-METHYLTRANSFERASE (COMT) PDB 6AK4 (CRYSTAL STRUCTURE OF HUMAN FTO IN COMPLEX WITH SMALL-MOLECULE INHIBITORS) LIGAND CODE = PD9 (link to the list of PDB complexes) Download experimental 3D coordinates of PD9 with added hydrogens | Catechol O-methyltransferase UNIPROT P21964 COMT more at DrugCentral | EMA | |||
