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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ATORVASTATIN
| ATORVASTATIN |
CARDIOVASCULAR | ORAL | Tmax 1.5 HOUR F 14 PERCENT VD 381 LITER PPB 98 PERCENT Cl 18.8 LITER / HOUR (EQN) HT 14 HOUR SOLUBILITY IS VERY SLIGHTLY SOLUBLE IN DISTILLED WATER PH 7.4 PHOSPHATE BUFFER | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE PDB 1HWK (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN) LIGAND CODE = 117 (link to the list of PDB complexes) Download experimental 3D coordinates of 117 with added hydrogens | 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR more at DrugCentral | EMA | |||
