| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MIFEPRISTONE
| MIFEPRISTONE | GENITO | ORAL | Cmax 4.6 NANOMOLAR Tmax 1.5 HOUR F 69 PERCENT PPB 98 PERCENT HT 18 HOUR SOLUBILITY POORLY SOLUBLE IN WATER | PROGESTERONE RECEPTOR PDB 3H52 (CRYSTAL STRUCTURE OF THE ANTAGONIST FORM OF HUMAN GLUCOCORTICOID RECEPTOR) LIGAND CODE = 486 (link to the list of PDB complexes) Download experimental 3D coordinates of 486 with added hydrogens | Glucocorticoid receptor UNIPROT P04150 NR3C1 -- Progesterone receptor UNIPROT P06401 PGR more at DrugCentral | EMA | |||
