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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VALSARTAN
| VALSARTAN |
CARDIOVASCULAR | ORAL | Tmax 3 HOUR F 25 PERCENT VD 17 LITER PPB 95 PERCENT Cl 2 LITER / HOUR HT 6 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | TYPE-1 ANGIOTENSIN II RECEPTOR PDB 8DQT (HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH VALSARTAN) LIGAND CODE = U35 (link to the list of PDB complexes) Download experimental 3D coordinates of U35 with added hydrogens | Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 more at DrugCentral | EMA | |||
