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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RILUZOLE
| RILUZOLE | NERVOUS SYSTEM | ORAL | Cmax 739 NANOMOLAR F 60 PERCENT VD 245 LITER PPB 96 PERCENT HT 12 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS (PMID26311432) PDB 5V02 (A POSITIVE ALLOSTERIC MODULATOR BINDING POCKET IN SK2 ION CHANNELS IS SHARED BY RILUZOLE AND CYPPA) LIGAND CODE = 657 (link to the list of PDB complexes) Download experimental 3D coordinates of 657 with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A more at DrugCentral | EMA | |||
