| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALENDRONATE
| ALENDRONATE |
METABOLISM | ORAL | F 0.64 PERCENT VD 28 LITER PPB 78 PERCENT Cl 12 LITER / HOUR HT 87600 HOUR SOLUBILITY SOLUBLE IN WATER | FARNESYL PYROPHOSPHATE SYNTHASE PDB 5DZ2 (GEOSMIN SYNTHASE FROM STREPTOMYCES COELICOLOR N-TERMINAL DOMAIN COMPLEXED WITH THREE MG2+ IONS AND ALENDRONIC ACID) LIGAND CODE = 212 (link to the list of PDB complexes) Download experimental 3D coordinates of 212 with added hydrogens | Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS more at DrugCentral | EMA | |||
