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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZAFIRLUKAST
| ZAFIRLUKAST | RESPIRATORY SYSTEM | ORAL | Cmax 567 NANOMOLAR Tmax 3 HOUR VD 70 LITER PPB 99 PERCENT Cl 20 LITER / HOUR HT 10 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PEPTIDE LEUKOTRIENE RECEPTOR LTD4 PEPTIDE LEUKOTRIENE RECEPTOR LTE4 PDB 6RZ5 (XFEL CRYSTAL STRUCTURE OF THE HUMAN CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH ZAFIRLUKAST) LIGAND CODE = ZLK (link to the list of PDB complexes) Download experimental 3D coordinates of ZLK with added hydrogens | Cysteinyl leukotriene receptor 1 UNIPROT Q9Y271 CYSLTR1 more at DrugCentral | EMA | |||
