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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GLIMEPIRIDE
| GLIMEPIRIDE |
METABOLISM | ORAL | Cmax 353 NANOMOLAR Tmax 2.5 HOUR F 100 PERCENT VD 8.8 LITER PPB 95.5 PERCENT Cl 2.8 LITER / HOUR HT 5.08 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL PDB 4YVX (CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLIMEPIRIDE) LIGAND CODE = GMR (link to the list of PDB complexes) Download experimental 3D coordinates of GMR with added hydrogens | Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 more at DrugCentral | EMA | |||
