| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BRIMONIDINE
| BRIMONIDINE |
SENSORY | OPHTHALMIC TOPICAL | Cmax 0.102 NANOMOLAR Tmax 2 HOUR PPB 29 PERCENT HT 3 HOUR SOLUBILITY SOLUBLE IN WATER 34 MILLIGRAM / MILLILITER | ALPHA-2 ADRENERGIC RECEPTOR PDB 7EJ8 (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO BRIMONIDINE) LIGAND CODE = J59 (link to the list of PDB complexes) Download experimental 3D coordinates of J59 with added hydrogens | Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B more at DrugCentral | EMA | |||
