| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACARBOSE
| ACARBOSE | METABOLISM | ORAL | Tmax 1 HOUR F 2 PERCENT VD 20.8 LITER (65 KILOGRAM) Cl 8.5 LITER / HOUR (65 KILOGRAM) HT 2 HOUR SOLUBILITY SOLUBLE IN WATER | LYSOSOMAL ALPHA-GLUCOSIDASE PANCREATIC ALPHA-AMYLASE PDB 5HQA (A GLYCOSIDE HYDROLASE FAMILY 97 ENZYME IN COMPLEX WITH ACARBOSE FROM PSEUDOALTEROMONAS SP. STRAIN K8) LIGAND CODE = ACR (link to the list of PDB complexes) Download experimental 3D coordinates of ACR with added hydrogens | Maltase-glucoamylase, intestinal UNIPROT O43451 MGAM -- Pancreatic alpha-amylase UNIPROT P04746 AMY2A more at DrugCentral | EMA | |||
