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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUVOXAMINE
| FLUVOXAMINE | NERVOUS SYSTEM | ORAL | Cmax 1.71 MICROMOLAR Tmax 5.5 HOUR F 53 PERCENT VD 1625 LITER (65 KILOGRAM) PPB 80 PERCENT Cl 72 LITER / HOUR (EQN) HT 15.6 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | SEROTONIN TRANSPORTER (SERT) PDB 6AWP (X-RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH FLUVOXAMINE AT THE CENTRAL SITE) LIGAND CODE = FVX (link to the list of PDB complexes) Download experimental 3D coordinates of FVX with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
