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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LAMOTRIGINE

LAMOTRIGINE


ATC N03AX09

NERVOUS SYSTEM
ANTICONVULSANT
ANTIEPILEPTIC
PHENYLTRIAZINE
TREATMENT OF BIPOLAR I DISORDER
SODIUM CHANNEL BLOCKER

ORAL

Tmax 1.7 HOUR

F 98 PERCENT

VD 71.5 LITER (65 KILOGRAM)

PPB 55 PERCENT

Cl 2.2 LITER / HOUR (65 KILOGRAM)

HT 25.4 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER (0.17 MILLIGRAM / MILLILITER)

VOLTAGE-SENSITIVE SODIUM CHANNEL

PDB 8THH (CRYO-EM STRUCTURE OF NAV1.7 WITH LTG)

LIGAND CODE = IYJ (link to the list of PDB complexes)

Download experimental 3D coordinates of IYJ with added hydrogens

Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A

more at DrugCentral

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