| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ERGOTAMINE
| ERGOTAMINE | NATURAL MOLECULE (link)
NERVOUS SYSTEM | ORAL RECTAL INHALATION SUBLINGUAL | Cmax 3.3 MICROMOLAR (0.5 MILLIGRAM IM ,PMID6627380) Tmax 0.5 HOUR F 62 PERCENT VD 120 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 44 LITER / HOUR (65 KILOGRAM) HT 2.25 HOUR | ALPHA ADRENERGIC RECEPTOR PDB 5TUD (STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR RECOGNITION OF THE HUMAN SEROTONIN 2B RECEPTOR BY AN ANTIBODY) LIGAND CODE = ERM (link to the list of PDB complexes) Download experimental 3D coordinates of ERM with added hydrogens | 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D more at DrugCentral | EMA | |||
