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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FINASTERIDE
| FINASTERIDE |
DERMATOLOGICALS | ORAL | Cmax 99.4 NANOMOLAR Tmax 1.5 HOUR F 63 PERCENT VD 76 LITER PPB 90 PERCENT Cl 9.9 LITER / HOUR HT 6 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | 5-ALPHA DEHYDROGENASE PDB 3G1R (CRYSTAL STRUCTURE OF HUMAN LIVER 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP AND FINASTERIDE. RESOLUTION 1.70 A) LIGAND CODE = FIT (link to the list of PDB complexes) Download experimental 3D coordinates of FIT with added hydrogens | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT P31213 SRD5A2 -- 3-oxo-5-alpha-steroid 4-dehydrogenase 1 UNIPROT P18405 SRD5A1 more at DrugCentral | EMA | |||
