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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VENLAFAXINE (has an active metabolite)

VENLAFAXINE


ATC N06AX16

NERVOUS SYSTEM
ANTIDEPRESSANT
ANALGESIC
SEROTONIN REUPTAKE INHIBITORS

ORAL

Cmax 812 NANOMOLAR

Tmax 2 HOUR

F 92 PERCENT

VD 487 LITER (65 KILOGRAM)

PPB 27 PERCENT

Cl 84.5 LITER / HOUR (65 KILOGRAM)

HT 5 HOUR

SOLUBILITY 572 MILLIGRAM / MILLILITER IN WATER (LOGP 0.43)

SEROTONIN REUPTAKE TRANSPORTER

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

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