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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TACRINE DISCONTINUED
| TACRINE | NERVOUS SYSTEM | ORAL | Tmax 1.5 HOUR F 17 PERCENT VD 349 LITER PPB 55 PERCENT Cl 218 LITER / HOUR (65 KILOGRAM) HT 3 HOUR SOLUBILITY FREELY SOLUBLE IN DISTILLED WATER | CHOLINESTERASE PDB 2AOW (HISTAMINE METHYLTRANSFERASE (NATURAL VARIANT I105) COMPLEXED WITH THE ACETYLCHOLINESTERASE INHIBITOR AND ALTZHEIMER'S DISEASE DRUG TACRINE) LIGAND CODE = THA (link to the list of PDB complexes) Download experimental 3D coordinates of THA with added hydrogens | Acetylcholinesterase UNIPROT P22303 ACHE -- Cholinesterase UNIPROT P06276 BCHE more at DrugCentral | EMA | |||
