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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FOSCARNET

FOSCARNETNATURAL MOLECULE (link)


ATC J05AD01

ANTIINFECTIVES
ANTIVIRAL
CHELATE DIVALENT METAL IONS
INHIBITS REPLICATION OF HERPES VIRUSES CMV, HSV-1 AND HSV-2

INJECTION

Cmax 623 MICROMOLAR

VD 33.8 LITER (65 KILOGRAM)

PPB 16 PERCENT

Cl 7.1 LITER / HOUR

HT 3.3 HOUR

DNA POLYMERASE

PDB 1NKI (CRYSTAL STRUCTURE OF THE FOSFOMYCIN RESISTANCE PROTEIN A (FOSA) CONTAINING BOUND PHOSPHONOFORMATE)

LIGAND CODE = PPF (link to the list of PDB complexes)

Download experimental 3D coordinates of PPF with added hydrogens

DNA polymerase catalytic subunit UNIPROT P04293

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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