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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PAROXETINE
| PAROXETINE | NERVOUS SYSTEM | ORAL | Cmax 187 NANOMOLAR Tmax 5.2 HOUR VD 1170 LITER (65 KILOGRAM) PPB 94 PERCENT Cl 70.2 LITER / HOUR (65 KILOGRAM) HT 21 HOUR SOLUBILITY OF 5.4 MILLIGRAM / MILLILITER IN WATER | SEROTONIN TRANSPORTER PDB 6F6I (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH PAROXETINE) LIGAND CODE = 8PR (link to the list of PDB complexes) Download experimental 3D coordinates of 8PR with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
