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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ONDANSETRON
| ONDANSETRON | METABOLISM | INJECTION ORAL | Cmax 0.34 MICROMOLAR VD 107 LITER (65 KILOGRAM) PPB 73 PERCENT Cl 24.7 LITER / HOUR (65 KILOGRAM) HT 3.5 HOUR SOLUBILITY SOLUBLE IN WATER | 5-HYDROXYTRYPTAMINE 3 RECEPTOR PDB 6W1M (CRYO-EM STRUCTURE OF 5HT3A RECEPTOR IN PRESENCE OF ONDANSETRON) LIGAND CODE = S87_6W1M (link to the list of PDB complexes) Download experimental 3D coordinates of S87_6W1M with added hydrogens | 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A more at DrugCentral | EMA | |||
