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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZOLPIDEM
| ZOLPIDEM | NERVOUS SYSTEM | ORAL SUBLINGUAL | Cmax 394 NANOMOLAR Tmax 1.6 HOUR VD 31.5 LITER (65 KILOGRAM) PPB 92.5 PERCENT Cl 16.7 LITER / HOUR HT 2.5 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 8DD2 (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS ZOLPIDEM) LIGAND CODE = R5R (link to the list of PDB complexes) Download experimental 3D coordinates of R5R with added hydrogens | Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
