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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LEVAMLODIPINE
| LEVAMLODIPINE AMLODIPINE |
CARDIVASCULAR | ORAL | Tmax 8 HOUR F 77 PERCENT VD 1365 LITER (65 KILOGRAM) PPB 93 PERCENT Cl 27.3 LITER / HOUR (65 KILOGRAM) HT 40 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | CALCIUM CHANNEL PDB 5KMD (STRUCTURE OF CAVAB IN COMPLEX WITH AMLODIPINE) LIGAND CODE = 6UB (link to the list of PDB complexes) Download experimental 3D coordinates of 6UB with added hydrogens | Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D more at DrugCentral | EMA | |||
