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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SIMVASTATIN (has an active metabolite)
| SIMVASTATIN |
CARDIOVASCULAR | ORAL | Tmax 4 HOUR F 5 PERCENT PPB 95 PERCENT HT 4.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR more at DrugCentral | EMA | |||
