| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LIDOCAINE
| LIDOCAINE |
CARDIOVASCULAR | INJECTION TOPICAL ORAL SPINAL RECTAL IONTOPHORESIS BUCCAL PERIODONTAL INTRADERMAL INTRAMUSCULAR INTRAVENOUS OPHTHALMIC | Cmax 777 NANOMOLAR Tmax 0.5 HOUR VD 117 LITER (65 KILOGRAM) PPB 70 PERCENT Cl 57 LITER / HOUR HT 1.75 HOUR | SODIUM CHANNEL PDB 3JQZ (CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH LIDOCAINE) LIGAND CODE = LQZ (link to the list of PDB complexes) Download experimental 3D coordinates of LQZ with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A more at DrugCentral | EMA | |||
