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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OFLOXACIN
| OFLOXACIN |
ANTIINFECTIVES | ORAL OPHTHALMIC INJECTION OTIC | Cmax 8 MICROMOLAR (400 MILLIGRAM) Tmax 1.5 HOUR F 98 PERCENT VD 104 LITER (65 KILOGRAM) PPB 32 PERCENT Cl 9.7 LITER / HOUR (65 KILOGRAM) HT 4.5 HOUR (ONE DOSE) SOLUBILITY SLIGHTLY SOLUBLE IN AQUEOUS SOLUTIONS WITH PH 7 | DNA TOPOISOMERASE 4 DNA GYRASE PDB 2BML (OFLOXACIN-LIKE ANTIBIOTICS INHIBIT PNEUMOCOCCAL CELL WALL DEGRADING VIRULENCE FACTORS) LIGAND CODE = XED (link to the list of PDB complexes) Download experimental 3D coordinates of XED with added hydrogens | DNA gyrase subunit A UNIPROT P0AES4 gyrA more at DrugCentral | EMA | |||
