PROPOFOL (is an active metabolite) | PROPOFOL | ATC N01AX10
NERVOUS SYSTEM ANESTHETIC ANTICONVULSANTS ANTIEMETICS FREE RADICAL SCAVENGERS HYPNOTICS SEDATIVES GABA-A AGONIST | INJECTION | Cmax 21.9 MICROMOLAR (18 MILLIGRAM/KG) VD 305 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 150 LITER / HOUR HT 3.2 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA(A)) BETA-ADRENOCEPTOR (BETA-AR) (PMID21793316) PDB 5MVN (X-RAY STRUCTURE OF THE M205W MUTANT OF GLIC IN COMPLEX WITH PROPOFOL) LIGAND CODE = PFL (link to the list of PDB complexes) Download experimental 3D coordinates of PFL with added hydrogens | GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |