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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| URSODIOL
| URSODIOL | NATURAL MOLECULE (link) METABOLISM | ORAL | PPB 70 PERCENT SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | HYDROXYSTEROID DEHYDROGENASE, BILE ACID BINDING PROTEIN (PMID22223860) PDB 1IHI (CRYSTAL STRUCTURE OF HUMAN TYPE III 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, BILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED WITH NADP+ AND URSODEOXYCHOLATE) LIGAND CODE = IU5 (link to the list of PDB complexes) Download experimental 3D coordinates of IU5 with added hydrogens | Bile acid receptor UNIPROT Q96RI1 NR1H4 more at DrugCentral | EMA | |||
