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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMODIAQUINE DISCONTINUED (has an active metabolite)
| AMODIAQUINE | ANTIPARASITIC | ORAL | Cmax 85.8 NANOMOLAR (PMID21709098) Tmax 1.46 HOUR VD 46200 LITER Cl 2380 LITER / HOUR HT 12.4 HOUR | PDB 4FGZ (CRYSTAL STRUCTURE OF PHOSPHOETHANOLAMINE METHYLTRANSFERASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH AMODIAQUINE) LIGAND CODE = CQA (link to the list of PDB complexes) Download experimental 3D coordinates of CQA with added hydrogens | Unknown more at DrugCentral | EMA | |||
