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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MITOXANTRONE
| MITOXANTRONE | ANTINEOPLASTIC | INJECTION | VD 1610 LITER PPB 78 PERCENT Cl 30.8 LITER / HOUR HT 53 HOUR | DNA DNA TOPOISOMERASE 2 PDB 2KGP (STRUCTURAL BASIS FOR STABILIZATION OF THE TAU PRE-MRNA SPLICING REGULATORY ELEMENT BY NOVANTRONE (MITOXANTRONE)) LIGAND CODE = MIX (link to the list of PDB complexes) Download experimental 3D coordinates of MIX with added hydrogens | DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A more at DrugCentral | EMA | |||
