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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DICLOFENAC
| DICLOFENAC |
MUSCULO-SKELETAL | ORAL OPHTHALMIC TOPICAL INTRAVENOUS | Cmax 8 MICROMOLAR Tmax 2.3 HOUR F 50 PERCENT VD 91 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 34.9 LITER / HOUR HT 2.3 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 3IB0 (STRUCTURAL BASIS OF THE PREVENTION OF NSAID-INDUCED DAMAGE OF THE GASTROINTESTINAL TRACT BY C-TERMINAL HALF (C-LOBE) OF BOVINE COLOSTRUM PROTEIN LACTOFERRIN: BINDING AND STRUCTURAL STUDIES OF C-LOBE COMPLEX WITH DICLOFENAC) LIGAND CODE = DIF (link to the list of PDB complexes) Download experimental 3D coordinates of DIF with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
