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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BEPRIDIL DISCONTINUED
| BEPRIDIL | CARDIOVASCULAR | ORAL | Cmax 6.8 MICROMOLAR PPB 99 PERCENT HT 42 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | CALCIUM CHANNEL PDB 1LXF (STRUCTURE OF THE REGULATORY N-DOMAIN OF HUMAN CARDIAC TROPONIN C IN COMPLEX WITH HUMAN CARDIAC TROPONIN-I(147-163) AND BEPRIDIL) LIGAND CODE = BEP (link to the list of PDB complexes) Download experimental 3D coordinates of BEP with added hydrogens | Voltage-dependent T-type calcium channel subunit alpha-1H UNIPROT O95180 CACNA1H -- Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C more at DrugCentral | EMA | |||
