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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MEXILETINE

MEXILETINE


ATC C01BB02

CARDIOVASCULAR
LOCAL ANESTHETIC
ANTIARRYTHMIC
SODIUM CHANNEL BLOCKER

ORAL

F 90 PERCENT

VD 360 LITER

PPB 55 PERCENT

Cl 30 LITER / HOUR

HT 11 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

SODIUM CHANNEL

Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A

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