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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIBAVIRIN
| RIBAVIRIN | ANTIINFECTIVES | INHALATION ORAL | Cmax 3.5 MICROMOLAR Tmax 1.7 HOUR F 64 PERCENT VD 2825 LITER PPB 0 PERCENT Cl 38.2 LITER / HOUR HT 43.6 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | ADENOSINE KINASE CYTOSOLIC PURINE 5'-NUCLEOTIDASE RNA-DIRECTED RNA POLYMERASE CATALYTIC SUBUNIT ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1 LARGE STRUCTURAL PROTEIN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 DNA PDB 3SFU (CRYSTAL STRUCTURE OF MURINE NOROVIRUS RNA DEPENDENT RNA POLYMERASE IN COMPLEX WITH RIBAVIRIN) LIGAND CODE = RBV (link to the list of PDB complexes) Download experimental 3D coordinates of RBV with added hydrogens | Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- NS5B protein UNIPROT Q8JXU8 NS5B more at DrugCentral | EMA | |||
