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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACETOHYDROXAMIC ACID
| ACETOHYDROXAMIC ACID | GENITO | ORAL | Tmax 0.625 HOUR F 100 PERCENT HT 7.5 HOUR (PMID649302) SOLUBILITY HIGHLY SOLUBLE IN WATER | UREASE MACROPHAGE METALLOELASTASE (MATRIX METALLOPROTEINASE-12 (MMP-12)) PDB 1Y93 (CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH ACETOHYDROXAMIC ACID AT ATOMIC RESOLUTION) LIGAND CODE = HAE (link to the list of PDB complexes) Download experimental 3D coordinates of HAE with added hydrogens | Bacterial urease UNIPROT Q03282 ureA more at DrugCentral | EMA | |||
