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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BUSPIRONE
| BUSPIRONE | NERVOUS SYSTEM | ORAL | Cmax 15.5 NANOMOLAR Tmax 1 HOUR F 90 PERCENT PPB 86 PERCENT HT 2.5 HOUR SOLUBILITY SOLUBLE IN WATER | 5-HYDROXYTRYPTAMINE 1A RECEPTOR PDB 8FYX (BUSPIRONE-BOUND SEROTONIN 1A (5-HT1A) RECEPTOR-GI1 PROTEIN COMPLEX) LIGAND CODE = YLX (link to the list of PDB complexes) Download experimental 3D coordinates of YLX with added hydrogens | 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A more at DrugCentral | EMA | |||
