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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MIDAZOLAM
| MIDAZOLAM | NERVOUS SYSTEM | INJECTION ORAL INTRAMUSCULAR NASAL INTRAVENOUS | Cmax 276.5 NANOMOLAR Tmax 0.5 HOUR F 90 PERCENT VD 133.2 LITER (65 KILOGRAM) PPB 97 PERCENT Cl 25.6 LITER / HOUR (65 KILOGRAM) HT 4.1 HOUR SOLUBILITY INSOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 5TE8 (CRYSTAL STRUCTURE OF THE MIDAZOLAM-BOUND HUMAN CYP3A4) LIGAND CODE = 08J (link to the list of PDB complexes) Download experimental 3D coordinates of 08J with added hydrogens | GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-5,beta-3,gamma-2 UNIPROT P18507 GABRG2 more at DrugCentral | EMA | |||
