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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ACYCLOVIR (is an active metabolite) (has an active metabolite)

ACYCLOVIR


ATC D06BB03

ANTIINFECTIVES
ANTIVIRAL AGAINST HERPES SIMPLEX VIRUS TYPES 1 (HSV-1), TYPES 2 (HSV-2) AND VARICELLA-ZOSTER VIRUS (VZV)

INJECTION TOPICAL ORAL BUCCAL OPHTHALMIC

Cmax 107 MICROMOLAR

F 15 PERCENT

VD 46 LITER (65 KILOGRAM)

PPB 21 PERCENT

Cl 19.9 LITER / HOUR (65 KILOGRAM)

HT 2.5 HOUR

SOLUBILITY 100 MILLIGRAM / MILLILITER IN WATER

THYMIDINE KINASE

PDB 5I3C (CRYSTAL STRUCTURE OF E.COLI PURINE NUCLEOSIDE PHOSPHORYLASE WITH ACYCLOGUANOSINE)

LIGAND CODE = AC2 (link to the list of PDB complexes)

Download experimental 3D coordinates of AC2 with added hydrogens

DNA polymerase catalytic subunit UNIPROT P04293 -- DNA polymerase catalytic subunit UNIPROT P09252

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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