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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BUPROPION
| BUPROPION |
NERVOUS SYSTEM | ORAL | Cmax 597 NANOMOLAR Tmax 2 HOUR VD 1950 LITER PPB 84 PERCENT Cl 209 LITER / HOUR HT 21 HOUR SOLUBILITY HIGHLY SOLUBLE IN WATER | DOPAMINE TRANSPORTER NOREPINEPHRINE TRANSPORTER | Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 more at DrugCentral | EMA | |||
