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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DILTIAZEM
| DILTIAZEM | CARDIOVASCULAR | ORAL INJECTION INTRAVENOUS | F 40 PERCENT VD 266 LITER (65 KILOGRAM) PPB 75 PERCENT Cl 50.7 LITER / HOUR (65 KILOGRAM) HT 3.75 HOUR SOLUBILITY SOLUBLE IN WATER | VOLTAGE-DEPENDENT CALCIUM CHANNEL PDB 6JPB (RABBIT CAV1.1-DILTIAZEM COMPLEX) LIGAND CODE = C9F (link to the list of PDB complexes) Download experimental 3D coordinates of C9F with added hydrogens | Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C more at DrugCentral | EMA | |||
