| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VERAPAMIL
| VERAPAMIL |
CARDIOVASCULAR | INJECTION ORAL INTRAVENOUS | Cmax 881 NANOMOLAR Tmax 1.5 HOUR F 13 PERCENT VD 240.5 LITER (65 KILOGRAM) PPB 90 PERCENT Cl 70.2 LITER / HOUR (65 KILOGRAM) HT 5.1 HOUR SOLUBILITY SOLUBLE IN WATER | VOLTAGE-DEPENDENT CALCIUM CHANNEL PDB 7QKR (CRYO-EM STRUCTURE OF ABC TRANSPORTER STE6-2P FROM PICHIA PASTORIS WITH VERAPAMIL AT 3.2 A RESOLUTION) LIGAND CODE = I6H (link to the list of PDB complexes) Download experimental 3D coordinates of I6H with added hydrogens | Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1S UNIPROT Q13698 CACNA1S more at DrugCentral | EMA | |||
