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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NIFEDIPINE
| NIFEDIPINE |
CARDIOVASCULAR | ORAL | Cmax 332 NANOMOLAR Tmax 0.5 HOUR F 86 PERCENT VD 51.3 LITER (65 KILOGRAM) PPB 95 PERCENT Cl 31.1 LITER / HOUR HT 2 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | VOLTAGE-DEPENDENT CALCIUM CHANNEL PDB 6JP5 (RABBIT CAV1.1-NIFEDIPINE COMPLEX) LIGAND CODE = C5U (link to the list of PDB complexes) Download experimental 3D coordinates of C5U with added hydrogens | Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D -- Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C more at DrugCentral | EMA | |||
