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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PROPYLTHIOURACIL
| PROPYLTHIOURACIL | HORMONES | ORAL | Cmax 105.8 MICROMOLAR (PMID6689066) Tmax 0.75 HOUR VD 22.1 LITER (65 KILOGRAM) PPB 82 PERCENT Cl 12.09 LITER / HOUR (65 KILOGRAM) HT 1.3 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | THYROPEROXIDASE (PMID12755690) PDB 5HPW (MODE OF BINDING OF ANTITHYROID DRUG, PROPYLTHIOURACIL TO LACTOPEROXIDASE: BINDING STUDIES AND STRUCTURE DETERMINATION) LIGAND CODE = 3CJ (link to the list of PDB complexes) Download experimental 3D coordinates of 3CJ with added hydrogens | Thyroid peroxidase UNIPROT P07202 TPO -- Type I iodothyronine deiodinase UNIPROT P49895 DIO1 more at DrugCentral | EMA | |||
