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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
OXYMETAZOLINE

OXYMETAZOLINE


ATC D11AX27
ATC R01AA05
ATC R01AB07
ATC S01GA04

RESPIRATORY SYSTEM
ADRENERGIC ALPHA 1 AND ALPHA 2 AGONIST
NASAL DECONGESTANT

OPHTHALMIC NASAL TOPICAL ALPHA-2A ADRENERGIC RECEPTOR
ALPHA-1A ADRENERGIC RECEPTOR

PDB 7EJK (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO OXYMETAZOLINE)

LIGAND CODE = J5C (link to the list of PDB complexes)

Download experimental 3D coordinates of J5C with added hydrogens

Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B

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