| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CAPTOPRIL
| CAPTOPRIL | CARDIOVASCULAR | ORAL | Tmax 1 HOUR F 75 PERCENT VD 48.7 LITER (65 KILOGRAM) PPB 27 PERCENT Cl 46.8 LITER / HOUR (65 KILOGRAM) HT 2 HOUR SOLUBILITY SOLUBLE IN WATER (160 MILLIGRAM / MILLILITER) | ANGIOTENSIN-CONVERTING ENZYME (ACE) PDB 1UZF (COMPLEX OF THE ANTI-HYPERTENSIVE DRUG CAPTOPRIL AN THE HUMAN TESTICULAR ANGIOTENSIN I-CONVERTING ENZYME) LIGAND CODE = MCO (link to the list of PDB complexes) Download experimental 3D coordinates of MCO with added hydrogens | Angiotensin-converting enzyme UNIPROT P12821 ACE more at DrugCentral | EMA | |||
