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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMILORIDE
| AMILORIDE | CARDIOVASCULAR | ORAL | Tmax 3.5 HOUR HT 7.5 HOUR | AMILORIDE-SENSITIVE SODIUM CHANNEL UROKINASE-TYPE PLASMINOGEN ACTIVATOR PDB 4NTX (STRUCTURE OF ACID-SENSING ION CHANNEL IN COMPLEX WITH SNAKE TOXIN AND AMILORIDE) LIGAND CODE = AMR (link to the list of PDB complexes) Download experimental 3D coordinates of AMR with added hydrogens | Amiloride-sensitive sodium channel, ENaC UNIPROT P37088 SCNN1A more at DrugCentral | EMA | |||
