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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMOXAPINE

AMOXAPINE


ATC N06AA17

NERVOUS SYSTEM
ANTIDEPRESSANT
BLOCKS THE REUPTAKE OF NOREPINEPHRINE AND TO A LESSER EXTENT SEROTONIN INTO THEIR RESPECTIVE NEURONS
BLOCKS THE RESPONSE OF DOPAMINERGIC RECEPTORS TO DOPAMINE
ACTS ON MULTIPLE RECEPTORS AND CHANNELS (PMID24294487)

ORAL

Cmax 215 NANOMOLAR

Tmax 1.5 HOUR

PPB 90 PERCENT

HT 8 HOUR

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

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